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There are two proteins known to control muscle size and quantity: Myostatin and Activin A
Myostatin, a protein naturally produced by the body, limits muscle size. Activin A limits muscle differentiation to increase number.
Myostatin is a member of the transforming growth factor-β superfamily.
Originally discovered in 1997 by biogeneticists, they found that mice lacking the code for myostatin had roughly twice the size of normal mice. Later, natural deficiencies in various types of myostatin were found in some breeds of cattle, sheep, and humans, in each case the result was a dramatic increase in muscle mass, leading to the discovery of the role of myostatin in muscle. The relationship between - myostatin prevents muscle growth.
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